/Nutrition and Prediabetes – BionicOldGuy

Nutrition and Prediabetes – BionicOldGuy

As I discussed in my previous post there may be some fascinating and helpful info in Dr. Michael Greger’s ebook How Not To Weight loss program on the relation between what and how we eat and prediabetes. This subject is necessary to me as a result of an excellent good friend of mine was lately recognized with prediabetes, and has been making heroic efforts in her consuming to deal with it with out medicine. Insulin resistance is the strongly associated to prediabetes, which is chronically elevated blood sugar (glucose). Typically the 2 phrases are used interchangeably. One other time period is carbohydrate intolerance. As a final little bit of terminology, insulin sensitivity is the other of insulin resistance. We would like our cells to have excessive insulin sensitivity which is identical as low insulin resistance. Excessive insulin sensitivity additionally means excessive carb tolerance. Prediabetes is recognized with an abnormally excessive studying on an hbA1c check, which signifies your common blood glucose stage over the past couple of months.


So first the fundamentals. When meals is digested our blood glucose stage goes up. This indicators to the pancreas to secrete insulin, which prompts the muscle mass and liver to obtain the vitality. It additionally prompts the fats cells to cease releasing vitality, since there are available energy that should be cleared from the blood. Extra glucose within the blood has varied dangerous uncomfortable side effects so it’s necessary for this to occur in a well timed method. As well as, the response to the surplus glucose is for the pancreas to pump out extra insulin, resulting in elevated insulin ranges within the blood, which has its personal dangerous results

Cells can turn out to be immune to the impact of insulin, in order that not sufficient sugar is taken out of the blood in response to a traditional dose of insulin. Some authors make the analogy that the insulin lock now not suits within the cells’ keyhole, however I desire Dr Greger’s analogy of a clogged drain. So insulin resistance reduces the outflow of sugar from the blood. The influx of sugar is managed by the meals we eat, particularly its glycemic load: how a lot and how shortly the blood sugar rises in response to a selected variety of energy of meals consumed.

Refined carbohydrates have the worst glycemic load, so chopping again on them is an efficient approach to “flip down the faucet” of sugar influx. It could seem to be a good suggestion to chop again on all carbs, however that is failing to tell apart between “unhealthy” (high-glycemic load) and “good” (low-glycemic load) carbs. You don’t have to chop down on all carbs to cut back blood sugar ranges, simply unhealthy carbs. Additionally, carbs should not the one meals that trigger insulin spiking. For instance, beef, which comprises no carbs, has a surprisingly excessive insulin response.

Whereas it’s a good suggestion to “flip down the faucet”, the key query I typically don’t see addressed is “why is the drain clogged” and what can we do to unclog it? Why did my good friend all of a sudden turn out to be insulin resistant in her 60s? Particularly in her case, as a result of she doesn’t test any of the plain bins: she is regular weight, bodily energetic, and eats a more healthy food plan than the usual American food plan.

Intramyocellular lipids and insulin resistance
From Dr Neal Barnard’s Ted Discuss
“Tackling diabetes with a daring new dietary method”

It’s by now properly established that the insulin resistance is strongly related to extra accumulation of intramyocellular lipids, or fats caught inside muscle cells, and many specialists argue that that is actually the trigger of insulin resistance. We don’t need a cross-section of our muscle mass to appear like a marbled steak. Elevated blood fats (lipid) ranges result in elevated intramyocellular lipids. And what we eat impacts our blood lipid ranges. This makes consuming a reduced-fat food plan seem to be a good suggestion, however excessive triglycerides means extreme fats within the bloodstream, which will be brought on by different kinds of extra energy, and the recommendations to decrease triglycerides embrace train, avoiding sugar and different refined carbs, and reducing saturated fats consumption.

That is sort of what I new going into studying How Not To Weight loss program however I picked up a variety of new data there. Here’s a abstract of the brand new stuff I discovered:

  • “These consuming plant-based diets common considerably decrease insulin ranges and have much less insulin resistance, even in comparison with nonvegetarians on the similar physique weight. In actual fact, those that eat meat have as much as 50 % larger insulin ranges of their bloodstreams” [1-4]. Intervention research confirmed important enchancment by placing sufferers with sort II diabetes on a plant-based food plan [5]. There’s a good dialogue about how efficient a plant-based food plan is in stopping and treating diabetes in Dr. Greger’s video “The Best Diet for Diabetes“,
  • Our intestine micro organism play an enormous position in carb tolerance. Bifodobacteria are good intestine bugs we wish to have, and bifodogenic meals encourages their development. Sadly, some persons are illiberal of a sort of meals name fodmaps, which is related to irritable bowel symptom amongst different issues. However a low-fodmap diet can result in decrease ranges of bifodobacteria [6] So it appears those that are on a low fodmap food plan must work more durable at consuming different meals allowed on their food plan which can be related to good intestine bugs.
  • Berries enhance insulin sensitivity, and consuming them together with different meals, even unhealthy carbs, blunts the insulin response to them. Consuming extra berries can general result in decrease insulin resistance [7].
  • “Including simply two teaspoons of vinegar to a high-glycemic meal (a bagel and juice) reduces the blood sugar spike by 23 %… A meta-analysis of 11 such research discovered that vinegar taken with a meal considerably improves each blood sugar and insulin responses, and it didn’t appear to matter what sort of vinegar was used” [8]. As to how this works:”The thriller was solved when a analysis staff in Greece demonstrated that vinegar consumption improves the uptake of blood sugar by our muscle mass” [9].
  • This subsequent tidbit will get again to the meal-timing suggestion in my earlier submit: We’re considerably extra insulin delicate within the morning in comparison with the night. So avoiding larger glycemic meals within the night is particularly necessary for blood sugar management [10].


The suggestions mentioned above nonetheless maintain: transfer extra, eat much less refined carbs, eat much less saturated fats, eat extra excessive fiber meals together with fruits and veggies. Within the mild of the decrease insulin resistance related to plant-based consuming. shifting in direction of decrease animal protein consumption and larger plant protein (like extra beans, much less meat) additionally looks like a good suggestion. As well as, there are some tweaks like consuming berries along with your meals, consuming extra within the morning and much less at evening (particularly avoiding larger glycemic meals at evening), and including vinegar to your meals (Dr. Greger had some strategies about vinegar with breakfast, however I need to admit I’ve not tried that step but). And don’t overlook to work in your stress: we are likely to eat junkier meals when wired. Fun physical activities and meditation (sitting or in movement) each assist.


  1. Valachovicová M, Krajcovicová-Kudlácková M, Blazícek P, Babinská Okay. No proof of insulin resistance in regular weight vegetarians. A case management research. Eur J Nutr, 2006.
  2. Kuo CS, Lai NS, Ho LT, Lin CL. Insulin sensitivity in Chinese language ovo-lactovegetarians in contrast with omnivores. Eur J Clin Nutr. 2004.
  3. Toth MJ, Poehlman ET. Sympathetic nervous system exercise and resting metabolic fee in vegetarians. Metab Clin Exp. 1994
  4. Hung CJ, Huang PC, Li YH, Lu SC, Ho LT, Chou HF. Taiwanese vegetarians have larger insulin sensitivity than omnivores. Br J Nutr. 2006.
  5. Barnard, R, Jung, T, and Inkeles, S, “Weight loss program and Train within the Therapy of NIDDM: The necessity for early emphasis”, Diabetes Care, 1994.
  6. Hill P, Muir JG, Gibson PR. Controversies and current developments of the low-FODMAP food plan. Gastroenterol Hepatol (N Y). 2017
  7. Törrönen R, Kolehmainen M, Sarkkinen E, Mykkänen H, Niskanen L. Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in wholesome ladies. Am J Clin Nutr. 2012
  8. Shishehbor F, Mansoori A, Shirani F. Vinegar consumption can attenuate postprandial glucose and insulin responses; a scientific evaluate and meta-analysis of medical trials. Diabetes Res Clin Pract. 2017
  9. Mitrou P, Petsiou E, Papakonstantinou E, et al. Vinegar consumption will increase insulin-stimulated glucose uptake by the forearm muscle in people with sort 2 diabetes. J Diabetes Res. 2015
  10. Bo S, Fadda M, Castiglione A, et al. Is the timing of caloric consumption related to variation in diet-induced thermogenesis and within the metabolic sample? A randomized cross-over research. Int J Obes (Lond). 2015